Here is the sentence again:

Syed finally decided to clean out his disorganized book bag, old US Government handouts, math notes from Intermediate Algebra, leaky ballpoint pens, and a smashed banana littered the inside.

Syed finally decided to clean out his disorganized book bag is a main clause. Old US Government handouts ... littered the inside is a second main clause. To connect these with just a comma is to create a comma splice, a major sentence error.

To fix the problem, you could put a period after bag and capitalize the O for old.

Go to the next sentence.

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